New Study Suggests Link Between Drinking Water Lithium Levels and Autism Diagnosis Risk
A recent study published in JAMA Pediatrics has found a modest association between exposure to tap water with higher levels of lithium during pregnancy and an increased risk of autism spectrum disorder (ASD) diagnosis in children. The study, which analyzed data from over 8,800 cases of ASD and 43,000 controls in Denmark, suggests that pregnant women exposed to higher levels of lithium may be at a slightly higher risk of having a child with ASD.
However, experts caution that the findings do not show a direct causal link between lithium exposure and autism diagnosis. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study and a professor of neurology at UCLA. "But we need more research to confirm this association."
The researchers found that children born to pregnant women exposed to higher levels of lithium had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure levels. The group with the highest exposure had a 46% higher risk than those at the lowest level.
Lithium is an alkali metal commonly used in batteries, grease, and air conditioners, as well as in the treatment of bipolar disorder and some blood disorders. Its levels in US drinking water are not regulated by the US Geological Survey.
While the study found a modest association between lithium exposure and ASD risk, experts emphasize that more research is needed to confirm this link. "Causation is definitely not proven," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We need to see if there's a viable mechanism by which a small amount of lithium can cause autism."
Other studies have suggested connections between ASD and environmental exposures to things like pesticides, air pollution, and phthalates, but none of them have identified any direct causal link.
The implications of the findings are complex, with some experts arguing that the association may be due to other factors. "We're bombarded with a variety of environmental stressors in our everyday lives," said Dr. Wiznitzer. "We need to figure out how to safely navigate them, and this may not be one that's high on our list."
The study highlights the need for further research into the potential effects of drinking water contaminants on fetal brain development and the risk of ASD diagnosis.
A recent study published in JAMA Pediatrics has found a modest association between exposure to tap water with higher levels of lithium during pregnancy and an increased risk of autism spectrum disorder (ASD) diagnosis in children. The study, which analyzed data from over 8,800 cases of ASD and 43,000 controls in Denmark, suggests that pregnant women exposed to higher levels of lithium may be at a slightly higher risk of having a child with ASD.
However, experts caution that the findings do not show a direct causal link between lithium exposure and autism diagnosis. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study and a professor of neurology at UCLA. "But we need more research to confirm this association."
The researchers found that children born to pregnant women exposed to higher levels of lithium had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure levels. The group with the highest exposure had a 46% higher risk than those at the lowest level.
Lithium is an alkali metal commonly used in batteries, grease, and air conditioners, as well as in the treatment of bipolar disorder and some blood disorders. Its levels in US drinking water are not regulated by the US Geological Survey.
While the study found a modest association between lithium exposure and ASD risk, experts emphasize that more research is needed to confirm this link. "Causation is definitely not proven," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We need to see if there's a viable mechanism by which a small amount of lithium can cause autism."
Other studies have suggested connections between ASD and environmental exposures to things like pesticides, air pollution, and phthalates, but none of them have identified any direct causal link.
The implications of the findings are complex, with some experts arguing that the association may be due to other factors. "We're bombarded with a variety of environmental stressors in our everyday lives," said Dr. Wiznitzer. "We need to figure out how to safely navigate them, and this may not be one that's high on our list."
The study highlights the need for further research into the potential effects of drinking water contaminants on fetal brain development and the risk of ASD diagnosis.