Lithium levels in tap water linked to higher risk of autism diagnosis in Danish study, but experts caution against direct link.
A new research published Monday found a modest association between lithium exposure during pregnancy and an increased risk of autism spectrum disorder (ASD) in Danish children. However, the researchers emphasize that this connection does not necessarily imply a causal link between the two.
According to the study, which was conducted on 8,842 cases of ASD and 43,864 participants without ASD, the concentration of lithium in drinking water is associated with an increased risk of ASD diagnosis. Specifically, children born to pregnant women exposed to higher levels of lithium had a 24% to 26% higher risk of ASD compared to those at lower exposure levels.
The researchers analyzed data from 151 public waterworks that served more than half of the Danish population and mapped out where pregnant people lived in relation to their exposure to lithium. While the study's findings suggest a link between lithium exposure and autism, they also acknowledge that the relationship is complex and requires further investigation.
Dr. Beate Ritz, co-author of the study, notes that "any drinking water contaminants that may affect the developing human brain deserve intense scrutiny." However, she emphasizes that more research is needed to confirm this association and understand its implications for public health policy.
The study's findings have sparked debate among experts, with some arguing that the connection between lithium exposure and autism is too weak to warrant significant concern. Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, notes that other research on the effects of lithium on pregnant women who take it for mental health disorders has not shown a link with autism spectrum disorder.
"The association is interesting, but causation is definitely not proven," Wiznitzer said. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
While some studies have suggested connections between ASD and environmental exposures to pesticides, air pollution, and phthalates, these findings are not conclusive, and more research is needed to determine whether these factors pose a direct risk to children's health.
As the debate continues, experts emphasize the need for caution when interpreting the study's findings. "There's a lot of speculation about environmental factors," Wiznitzer said. "We have to figure out how to basically safely navigate them."
A new research published Monday found a modest association between lithium exposure during pregnancy and an increased risk of autism spectrum disorder (ASD) in Danish children. However, the researchers emphasize that this connection does not necessarily imply a causal link between the two.
According to the study, which was conducted on 8,842 cases of ASD and 43,864 participants without ASD, the concentration of lithium in drinking water is associated with an increased risk of ASD diagnosis. Specifically, children born to pregnant women exposed to higher levels of lithium had a 24% to 26% higher risk of ASD compared to those at lower exposure levels.
The researchers analyzed data from 151 public waterworks that served more than half of the Danish population and mapped out where pregnant people lived in relation to their exposure to lithium. While the study's findings suggest a link between lithium exposure and autism, they also acknowledge that the relationship is complex and requires further investigation.
Dr. Beate Ritz, co-author of the study, notes that "any drinking water contaminants that may affect the developing human brain deserve intense scrutiny." However, she emphasizes that more research is needed to confirm this association and understand its implications for public health policy.
The study's findings have sparked debate among experts, with some arguing that the connection between lithium exposure and autism is too weak to warrant significant concern. Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland, notes that other research on the effects of lithium on pregnant women who take it for mental health disorders has not shown a link with autism spectrum disorder.
"The association is interesting, but causation is definitely not proven," Wiznitzer said. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
While some studies have suggested connections between ASD and environmental exposures to pesticides, air pollution, and phthalates, these findings are not conclusive, and more research is needed to determine whether these factors pose a direct risk to children's health.
As the debate continues, experts emphasize the need for caution when interpreting the study's findings. "There's a lot of speculation about environmental factors," Wiznitzer said. "We have to figure out how to basically safely navigate them."